Jen Hofmann

Hi! I'm a Senior ML Scientist II at Prescient Design, Genentech. My research lies at the intersection of machine learning, computational biology, and colloid physics. Within Genentech Large Molecule Drug Discovery, I develop and apply computational methods for therapeutic antibody design and optimization, focused on high concentration property prediction.

I completed my PhD at Stanford University in the lab of Professor Roseanna Zia on computational rheology, protein interactions, and mesoscale cell models. I earned my Bachelor's degree in Chemical Engineering with a minor in Literature from MIT. There, I worked with the late Professor Jim Swan on a number of computational soft matter projects.

My computational training is complemented by diverse wet lab experiences - including antibody interfacial rheology in the Fuller Group at Stanford and siRNA therapeutic design & delivery at the NCI. Outside of research, I enjoy soccer, cycling, jazz, hiking with my 5 y.o. heeler mix Nomi, and trying new craft beers.
Profile Photo

Publications

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A Wang; Z Sang; SD Stanton; JL Hofmann; S Izadi; E Park; J Ludwiczak; M Kirchmeyer; D Davidson; A Maier; T Pritsky; NC Frey; AM Watkins; F Seeger
ICLR 2025 Workshop on Generative and Experimental Perspectives for Biomolecular Design
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NC Frey*; I Hötzel*; SD Stanton*; R Kelly*; RG Alberstein*; ...; JL Hofmann; ... J Marioni; A Regev; Y Wu; K Cho; R Bonneau; V Gligorijevic
bioRxiv, 2025
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J Lin*; JL Hofmann*; A Leaver-Fay; WC Liang; S Vasilaki; E Lee; PO Pinheiro; N Tagasovska; JR Kiefer; Y Wu; F Seeger; R Bonneau; V Gligorijevic; A Watkins; K Cho; NC Frey
bioRxiv, 2025
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D Valverde-Mendez*; AM Sunol*; BP Bratton; MDelarue; JL Hofmann; JP Sheehan; Z Gitai; LJ Holt; JW Shaevitz; RN Zia
Proceedings of the National Academy of Sciences, 2025
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JL Hofmann; TS Yang; AM Sunol; RN Zia
Communications Biology, 2025
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G Wang; Z Varga; J Hofmann; IE Zarraga; JW Swan
Journal of Physical Chemistry B, 2018
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Z Varga; JL Hofmann; JW Swan
Journal of Fluid Mechanics, 2018
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KA Afonin; M Viard; I Kagiampakis; CL Case; MA Dobrovolskaia; J Hofmann; A Vrzak; M Kireeva; WK Kasprzak; VN KewalRamani; BA Shapiro
ACS Nano, 2015

Selected Awards